Commentary (Blanke)—Imatinib Mesylate: A Molecularly Targeted Therapy for Gastrointestinal Stromal Tumors
نویسنده
چکیده
Molecularly targeted therapy is a hot topic in oncology, and the development of imatinib mesylate (Gleevec) for gastrointestinal stromal tumors (GISTs) is one of our best examples of the successful translation of basic science research into effective treatment of malignancy. Dr. Eisenberg has thoroughly researched the impetus for the use of imatinib in GISTs and has methodically reviewed the results of several completed trials. He broadly discusses mechanisms of resistance to the drug and talks about future directions in GIST research. Dr. Eisenberg has successfully captured much of the early excitement surrounding the success of imatinib, and he appropriately mentions the possibility of applying targeted therapy to other solid tumors.
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